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Long-acting insulinotropic peptide

AuthorChangshan ConjuChem biological pharmaceutical R&D Co.,Ltd  Time2013/9/4 10:44:47  Viewed

   Long-acting insulinotropic peptide:The invention related to modified insulinotropic peptides, the invention related to new chemical reactivity insulinotropic peptide derivative, with a cell having a mobile blood protein functional groups on the carrier to form an effective covalent bond. Specifically, the invention related to new chemical reactivity of insulinotropic peptides such as glucagon-like peptide and exendin3 and exendin4 derivatives, with the effective flow of blood protein reactive functional group to form a covalent bond. The invention also related to novel chemical reactivity insulinotropic peptide derivatives and analogues thereof, can be effective on the flow of blood protein reactive functional group to form a covalent bond.
  The invention related to modified insulinotropic peptide, which contains a compound of the blood amino, hydroxy or mercapto group to form stable covalent bond reactive group.
  The invention further related to compositions containing said derivatives of insulinotropic peptide compositions and the compositions in the treatment of diabetes, the body of. In addition, related to increasing the expression of insulin, which comprises a mammalian pancreatic B-type islet cell an effective amount of the above disclosed modified insulinotropic peptides. The present invention also relates to use of the invention, the modified insulinotropic peptides to other insulinotropic peptide related diseases and conditions of treatment.

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